Genetic problems , down syndrome, hurlintong disease, diabetes, and Research Paper

Genetic problems , down syndrome, hurlintong disease, diabetes, and turner syndrome - Research Paper Example Sometimes errors can occur in the transmission of genetic material from parents to offspring or in the structure of the genetic material causing serious disorders in human beings. Structural chromosomal abnormalities arise when different enzymes are not able to repair several breaks in the pattern of chromosomes or even if they are able to do so these repairs are not specific enough to avoid the abnormality. These can be caused by chemicals, radiations, viruses, or any other type of abnormal event. These structural abnormalities are classified into four main classes respectively. These are Deletions, Translocations, Inversions and Ring Chromosome (Langman & Sadler 2006; Robbins et al 2005). Other names of deletion are gene deletion and deficiency mutation. Deletion is that type of genetic abnormality in which a sequence of DNA is absent in the chromosome or a part of chromosome is absent. It results in the loss of the genetic material from the chromosome. Translocation is also genetic aberration which occurs due to the rearrangement of the different parts of chromosome with nonhomologous chromosomes. Translocations are of two types that are reciprocal translocations and Robertsonian translocations. Reciprocal translocation is the translocation of genetic material between nonhomologous chromosome. These type of chromosomal translocations are harmless. When the two acrocentric chromosome fuse near the centromere resulting in loss of the short arm, this type of translocation is called Robertsonian translocation. In Robertsonian translocation the resulting karyotype in humans is 45 chromosomes. Inversion is that type of chromosomal abnormality in which a part of chromosome is split and introduced back to the same chromosome. Inversion is basically the aberration in a single chromosome itself and is not associated to other homologous or nonhomologous chromosome. Inversions are of two types paracentric and pericentric.

Castle bingo Essay Example | Topics and Well Written Essays - 2000 words

Castle bingo - Essay Example CRM integrates marketing, service and supply-chain functions in order to achieve greater efficiency in delivering greater value to discriminating customers. Consequently, CRM improves customer services, facilitates better integration of marketing tools, increases organisation revenues and reduces costs associated with customer services by a significant level (Richards & Jones, 2008). Castle Bingo and Benefits of Customer Relationship Management (CRM) The three primary elements of CRM have been described hereunder. Operational CRM Operational CRM consists of software packages that are used to efficiently arrange inbound and outbound customers interactions. Operational CRM aid in processes related with sales, customer service, marketing and automating communications. Service automation helps an organisation to manage service operations delivered through web, contact centre and face to face. Some of the significant benefits of operational CRM to Castle Bingo may include: Sales Force Aut omation Enterprise marketing Automation Customer Service and Support (Bhatnagar, 2012). Analytical CRM Analytical CRM involves analysing customer vital information in order to effectively meet the marketing and customer service goals and deliver appropriate message to the right customer at right time through appropriate channel. The significant benefit of Analytical CRM to Castle Bingo may involve Customer retention Segmentation and targeting Development of new products according to the customer’s specifications (Bhatnagar, 2012). Collaborative CRM Collaborative CRM comprises the system that facilitates customers to perform various services on their own through variety of interaction channels. It renders people process as well as data together and further facilities in channelling the data along with customer related information for ensuring proactive decision making. It ensures timely sharing of information and results in enhanced customer services. The major benefits of Col laborative CRM to Castle Bingo may involve: Providing effective customer communication across different channels, Increases the efficiency of online services and help in reducing customers service costs associated with offline services and Facilitate in better access to customers data during the time of interaction with customers (Bhatnagar, 2012). The Principles of Big Data and Metrics The data driven decision-making is currently being widely recognized and is viewed to be an increasing enthusiastic aspect related with the notion of ‘Big Data.’ Big Data refers to traditional enterprise data which comprises valuable information regarding the nature of the customers that is ascertained through CRM systems, web store transactions, ERP data as well as general ledger data. Furthermore, it also includes social data such as customers’ feedback streams, micro blogging internet sites like Twitter and social media like Facebook (Dijcks, 2012). The perception of Big Data c an primarily be attributed with four principles that have been discussed below. More Granular Information or Micro Segmentation The principle of micro segmentation can be

The American revolution 2 Essay Example | Topics and Well Written Essays - 1500 words

The American revolution 2 - Essay Example Americans were outraged. They were not given ample representation on the matter. They called it as "taxation without representation." This ignited different forms of opposition from the Americans like stopping the importage of British goods. Some even reacted violently by barricading a house where the stamps are stored and destroying it. A group called Sons of Liberty was formed and these lead the plea to repeal the law. Although the law was repealed, the parliament passed a Declaratory Act that affirmed the British's right to legislate laws that it wanted for its colonies. This was followed by the passage of the Tea Act to save the East India Company from bankruptcy. The law removes all duties imposed on British tea exported to America and these gave unfair advantage on other tea imports. Again, they resisted this law and it led to the infamous Boston Tea Party wherein some members of the Sons of Liberty boarded a British ship and threw off the imported tea to the sea. A few years later, the British parliament passed a number of laws, which are deemed unfair for the Americans. This prompted all colonies except Georgia to convene for the first time as the First Continental Congress to create a unified stand against unfair British policies and laws. Violence erupted elsewhere which were met by British forces. One of these events was the Boston Massacre wherein they fired into a mob. The confrontations escalated into a military conflict to the Battles of Lexington and Concord, the first of the battles between the British and Americans. These battles prom pted all of the thirteen colonies to again convene as the Second Continental Congress to direct the American war efforts and they appointed George Washington to lead and organize the army and finally on the 4th of July, they declared the independence of America. The Continental Congress provided the venue for different personalities coming from the colonies to pursue their own interests. But in the end, they were able to see that they have common interests and saw themselves as one people. During the First Continental Congress, they tried to push for reforms and the repealing of the laws but they were neglected. Situations worsen and it went to a full-scale rebellion against Great Britain. Eventually, they saw that they cannot pursue these interests as different colonies but should act as one and it was only through independence from British rule that it can be achieved. It was their inevitable choice. This was further strengthened by the framing of the Articles of Confederation by the Continental Congress and became as the first charter of the government. Although it wasn't until 1891 when all of the 13 colonies approved it, it was one step ahead of creating the United States of America. The Continental Congress also faced a lot of setbacks. One of these was due to the differences of the colonies interests, it cannot be avoided that they present different views and proposals. An example was the option to just reconcile with Great Britain and propose reforms. But because the war is ongoing and it really stirred American patriotism, only a few supported this stance and still opted to continue the war and eventually declaring their independence. 2. Discuss the costs and benefits of the American Revolution Who had the most to gain The most to lose Was the American

Marketing Financial Services Essay Example | Topics and Well Written Essays - 2500 words

Marketing Financial Services - Essay Example This paper will deal with in detail the issues and challenges faced by Barclays Bank as well as a clear and well drawn out SWOT analysis of the company. The paper will first provide an overview of the company and will also discuss in detail the reasons for choice of the bank. Overview of Company Barclays Banks has been one of the trusted and well known banks across almost 50 countries. The bank has been able to cater to the markets and provide the customers with excellent banking facilities for over three hundred years. Spread across fifty countries, the company employees around 145,000 employees and services almost 48 million customers worldwide. The company deals with several different activities and services like â€Å"retail banking, credit cards, corporate banking, investment banking, wealth management and investment management services with an extensive international presence in Europe, the Americas, Africa and Asia† (Barclays Bank, 2011). The bank is made of two main cl usters, i.e. Global Retail Banking and Corporate and Investment Banking and Wealth Management. Each of these clusters has a number of individual business units as well. Another major part of the company is the Group Center. The company is head by Group Chairman Marcus Agius and the Chief Executive is Robert E. Diamond, Jr. The company is headquartered in Churchill Place in London. It however caters to the markets across the world both for its products and services (Barclays Business, 2011). Reasons for Choice Barclay’s Bank has been recognised for its international nature and the bank has built its image across Asia, America, Europe and Africa. The company’s brand name and image that it has created allows it to become a name for every home. Also, Barclay has been extremely successful in marketing itself over the years (Barclays Sustainability, 2011). The bank has developed a strong brand image across the globe. Also, Barclay’s overall strategies and corporate fo cus is also an excellent example to study and analyse the SWOT. Hence this company proves to be an excellent example to study here. Barclay’s Strategy and Principles As in the case of every bank, the main aim of the company is to provide credit to businesses and households, to help improve their growth and jobs. Barclay has also constantly focused on improving its business by diversifying into different areas (Barclays Bank, 2011). A major attempt of the company is to increase its presence in the markets and segments, and this has clearly been achieved by means of innovative products and services for customers across the world (Barclay Card, 2011). All strategies of the company are based on three main aspects i.e. â€Å"Earn, Invest and Grow† (Barclays Bank, 2011). The group’s ambition and the overall commitment have grown the company to become a part of the universal banks. Barclays also has set down four main strategic priorities which include, a) To be able t o build the best bank in UK, accelerated and increased global growth, development of both retail as well as commercial activities across selected countries outside of the United Kingdom and last but not the least operational excellence (Barclays

Ocean Carriers Essay Example for Free

Ocean Carriers Essay Iron ore and coal imports will most probably decrease the upcoming year With the increasing supply of vessels should result in a market surplus By creating this surplus, prices will be driven down, since we will have limited demand and suppliers competing Average daily rates, based on historical numbers, have a direct relationship with the number of shipments. Only Accept the project if we sell after 25 years in a tax free environment Reject all of the following; sell after 15 years in both a tax and tax free environment, also after 25 years with a tax environment The longer the wait to sell; the better How Long Should Vessels Operate? The company’s current policy is to not operate ships older then 15 years old If Ocean Carrier operates for 25 years the NPV will be higher then if they operate for 15 years and sell the scrap metal (,368,557 vs. $2,238,411) The present value of the future cash flows exceeds the value of selling the scrap metal 10 years earlier. Hence there is greater value operating the vessel for an additional 10 years/ Iron and coal’s demand is expected to increase annually and the charter rates are expected to increase by annually for the life of the vessel. The company can generate more income if they decide to operate the ship for an additional 10 years.

Micronutrient Chart Essay Example for Free

Micronutrient Chart Essay Complete the table below. For each micronutrient listed, describe its function and identify common food sources. Then, review your Personal One-Day Intake Log and identify foods that provide substantial amounts of micronutrients. You do not need to identify every micronutrient found in every piece of food. List those foods in the My Food Choices column corresponding to the micronutrients they contain. Please answer each of the following questions with a maximum of 200 words. 1. What micronutrients are missing from your diet? What foods, that you enjoy, could you eat to supply these nutrients? 2. Micronutrient deficiencies can have many negative effects on your health. What long-term effects can you anticipate if your current deficiencies continue? General Questions General General Questions Resources: iProfile and WileyPLUS ® Read the instructions in the University of Phoenix Material: Micronutrient and Fast Food Presentation located on the student website to complete this assignment.   If you are having trouble making friends on campus, get involved in a club or two. Find any organized activity that you are interested in, and you will automatically be spending time with other students who share at least one of your passions. It can be helpful to have friends who are fellow students but not your immediate classmates. This archive file of SCI 220 Micronutrient Chart comprises: Complete the table below. For each micronutrient listed, describe its function and identify common food sources. Then, review your Personal One-Day Intake Log and identify foods that provide substantial amounts of  micronutrients. You do not need to identify every micronutrient found in every piece of food. List those foods in the My Food Choices column corresponding to the micr Click this link Now for Complete Course https://bitly.com/12C5XsD If you are having trouble making friends on campus, get involved in a club or two. Find any organized activity that you are interested in, and you will automatically be spending time with other students who share at least one of your passions. It can be helpful to have friends who are fellow students but not your immediate classmates. General Questions General General Questions Resources: iProfile and WileyPLUS ® Read the instructions in the University of Phoenix Material: Micronutrient and Fast Food Presentation located on the student website to complete this assignment.

Facilitating Change In Health And Social Care Social Work Essay

Facilitating Change In Health And Social Care Social Work Essay Change is a process of transitioning  from a current situation to a desired future condition. Whether we like change or not, we are all caught up in a never-ending cycle of change in our organizations. Some people welcome change and enjoy the uncertainty it often brings, thinking that it offers a new challenges and opportunities at work. Others are cautious about change, fearing that something valued will be altered or lost or that risk brings unnecessary stress. In care, health and social care services are essentially about people, both those who need to use services and those who provide services. People are sensitive to the impact of change and as a manager I have a particular responsibility to take care over how changes in services that are intended to deliver care within the organization. One of the reasons why change seems to be constant is that there are many potential stimuli for change and there are several factors driving change. The stimulus for change may come from inside an organization but it is more usual for it to come from outside. Change initiated within the organization is often a response to a force outside the organization that triggered the change. For example, factors that have a significant impact on health and social care services include government legislations and policies. Many aspects of health and social care are subject to legislation. New legal requirements emerge constantly as government seek to improve health and social care, often through introduction of systems to set standards and to control or modify service provision. Like the Health and Safety at Work Act 1974, this was enacted because of increasing numbers of accidents and incidents that happened in the past related to work. Its main purpose is to protect and minimize people from ha rm. It places a general duty on employers to ensure health, safety and welfare of all employees as far as is reasonably practicable. This legislation situates an impact not only on health care industry but all kinds of work. That is why until now it was expanded its scope, clarified responsibilities and responded to new circumstances as they have arisen without changing the overall principles of the original Act. Legislation also affects service provision though legislation relating to employment, health and safety, use of public funding and through related services including education and housing. Recently, the government commence key modification which affects the eligibility of all non-EU workers who wants to work in the UK. Those individuals must earn a minimum number of points. The new rules state the less points will be given for employees earning lower salaries in UK and no points to those who are paid less  £20,000 per annum compare to the old rules that give a minimum points for those workers having  £17,000 salary per year. It means the employer will have to pay new workers at least  £20,000. In addition, the care providers were enormously concerned about the present government removing the senior carers from shortage status because it might cause damage on the quality of care and in the business. Moreover, new technology is also a reason that is why change arises in health care setting. One great example is the development of internet. It change the way of sending information to the multi-disciplinary team through e-mail. Making it easier for senior staff to send and receive relevant information from GPs and other professionals and vice versa regarding service users condition while promoting privacy and confidentiality. It also change our ways of using records and libraries. Staffs in health and care services have access to an increasing range of information that is available to practitioners in health and social care. Service users expect us to make use of evidence in making decisions and database of best practice models are increasingly available. In my workplace, the management use the internet to provide trainings for staff which is more suitable and can be done in our own convenient time. For residence and relatives, its a fact that most of the relatives of our service u sers are far away from each other. However with the utilization of the internet, distance is not a big deal anymore. For relatives and services user who have personal computers or laptops can make conversation and see each other with the use of webcam and chat rooms through the internet. Service delivery is also influence by use of new developments in equipments. Like the new equipment acquired by Barts and The London NHS Trust the two state-of-the-art Lifeport organ transporters. It endow with a valuable sustenance for patients needing a kidney transplant. It stores healthy kidneys after they are removed from the donor before being transplanted into the recipient. This is a critical period for ensuring that the organ does not deteriorate and become unusable. Unlike before that they rely on ice to conserve the kidney, the new equipment maintains the organ in a fluid rich in nutrients and oxygen, which significantly extends the storage period. For the new equipments, it does change the old method to a new way that allows hope for more patients to have successful kidney transplants. In care home settings, the acquisition of new equipments like the air pressure mattress is indispensable equipment for anyone at high risk of developing pressure ulcers or who have existing pressure ulcers. The alternating pressure of the mattress depends on the weight of the service user allowing relieved on a regular basis and trim down the number of times a person needs to be turned, greatly enhancing the comfort of the very poorly or terminally ill. In addition, economic factors also drive change. These factors include the general prosperity of the country and its neighbourhood, the rate of unemployment, areas of poverty, the level of inflation and exchange rates in relationships involving other countries and currencies. The state of the economy affects the level of demand for goods and services, the prosperity of communities and the availability and cost of raw materials and labours. The economy tends to move in cycles, but these are not easy to predict. All services, whether public services, private services or charity provision, are affected by changes in the economy. At present, there were lots of changes in the health and social care sector due to the recent financial crisis that affects the economy of United Kingdom. As a result, the coalition government have wasted no time to save money in reshaping parts of the health services. According to the health secretary, the popular NHS direct services will be substitute with cheaper alternative. Under the governments plans, some strategic health authorities and hundreds of primary care trust are to be abolished affecting thousands of employees and service users. Examples of recent cost-cutting measures cited by professionals are hospital bed closures, pressure to give patients cheaper, slower-acting drugs, cuts to occupational health support, and reductions in community health services. Furthermore, according to a study, it make known that for the most part of job losses it involved frontline staff as patient services are withdrawn. Along with mounting numbers of patients are being deprived of treatm ent for conditions such as loss of sight, arthritis and infertility as the  NHS  increasingly rations healthcare in order to save money. But, the spending cuts done by the government does not only affect the health and social care sector but the life of Britons as a whole. It affects the sick, the disabled and Britains poorest families. Among the biggest cuts are only allowing claimants to have the replacement for Incapacity Benefit, the Employment and Support Allowance for one year, Cutting Disability Allowance for those people in care. Cutting Council Tax benefit by 10%. Reductions in the help given for childcare to working families, and slashing housing benefit for the under-35s by paying them the shared room rate instead of enough to live on their own etc., To be able to facilitate change in health and social care, as a manager I need to be able to understand the principles of change management. According to John Kotter, an authority of leadership and change, change has both an emotional and situational components and methods for managing each are expressed in his 8 step model. To value his model, as a managers there must be an understanding about the suppression and to cause employees emotion. During any period of change, a manager must deal with feelings of complacency, anger, false pride, arrogance, panic, exhaustion and anxiety among staffs. These are all emotions that can challenge and undermine attempts at promoting change. As managers I need to be able to turn these negative feelings into positive and proactive feelings such as faith, trusts urgency, hope, passion and enthusiasm which are emotions that promote change. On the first phase the model explained the phase of creating a climate for change. As a manager, there is need to develop a sense of urgency to staff. That action is needed regarding a foreseen difficulty. This can be done during meetings by explaining the situation through showing related videos and sharing stories. As the urgency grows among the staffs, as a manager, there is necessity to develop a guiding team that guide the change throughout the remaining steps. Members of the guiding team could be unit managers, senior carers or persons who have a relevant knowledge about the changes that occur in the organization, the ability to establish credibility and trusts to peers, the formal authority associated with managerial skill and the leadership. With the manager, alongside with the guiding team, must develop a vision expressed in a clear, concise statement about the direction in which the organization is headed. Engaging and enabling the whole organization is the second phase of Kotters model. Here, anxiety, anger, panic, among staff will rise because the manager or guiding team announces the impending change. Whenever, change is about to take place, people begin to wonder. That is why the guiding team needs to communicate to the individual or groups that are to be affected by change. And need to address these feelings and help staff to think and act in accordance with the new direction. An effective way to communicate the vision is to develop an engaging story that catches the attention of the change initiates. If there is a resistance to the staff at certain point, a dialogue between the guiding team and staff initiates a question and answer session. Staffs displays understanding when they realized the advantage, rewards and perquisites that they will gain once the change is completed. As the pathways to change are cleared, staffs must need to carefully choose and complete tasks that clear ly show that the change is succeeding. Tasks completed provide further urgency and momentum among the organization and lessen the impact of negative comments. At the final phase, the action plan is implemented fully allowing staff not to let up of the change. Collaboration occurs when staffs are willing to endorse or stand behind the change and displays commitment. As managers, at this phase, should sustain the change. It is done when a new way of operating has been shown to staff to succeed over the some minimum period of time Staffs at this point, displays advocacy that maintains the attitudes and behaviours supporting the change.. To relate this in my work, in my care home, there are recent changes that were implemented due staffs failing to do proper documentation. Firsts, the home manager scheduled a meeting and consultation to all the unit managers. At the meeting, to develop a sense of urgency among staff, she used a video based scenario regarding right documentation. The video shows the positive and negative effect of proper documentation to staffs, residents and management. In the meeting, everyone was asked about the ways to improve the situation. Then, decided that every staff should be knowledgeable and competent enough to do appropriate documentation at work through trainings and observations to make sure that they have the awareness, understanding and collaboration about the agenda of the meeting. On the other hand, the unit managers are to be the guiding team to lead, direct and show the proper way of documentation to unit staffs. Before the meeting ends, she makes sure that everyone understands ab out the directions in which the organization is headed and there would be recognition as the best unit that could implement the change. Finally, now every staff is confident regarding answering the forms in the care plans of every resident and certain to do the right documentation. The as proposed the guiding team use appraisal and supervision to measure the change. Plus the home manager monitored the change by evaluating the care plans of the residents with the help of a unit manager every end of the month for this change to become a culture in the care home.